10 Best Supplements for Cell Regeneration 2024
If you search online for stem cell supplements, you’re bound to find a long list. Do stem cell supplements really work? Figuring out what to make of all of these supplements can be pretty daunting, as each claims to be the best and greatest.
For example, to create a stem cell supplement, you could focus on the different ways that stem cells get impacted by supplement ingredients, like proliferation. This means that the substance helps stem cells make more of themselves. You then choose from some the ingredients below and you’ve got a new supplement. However, is this really what’s desired? Do you want more stem cells? Is that a good thing or a bad thing? What other impacts do these supplements have on stem cells?
The Stem Cell Supplement Game
For example, to create a stem cell supplement, you could focus on the different ways that stem cells get impacted by supplement ingredients, like proliferation or stem cell production. This means that the substance helps stem cells make more of themselves. You then choose from some the ingredients below and you’ve got a new supplement. However, is this really what’s desired? Do you want more stem cells? Is that a good thing or a bad thing? What other impacts do these supplements have on stem cells? All of this is largely unknown.
Specific Stem Cell Supplements
Here we’ll start with a few common supplements you might see on the grocery store shelf, to see what the research says about how they impact stem cells. Realize that many of the research studies that can be found on this topic may use a different stem cell type. Hence, we tried to focus mostly on mesenchymal stem cells.There are Different Stem Cell Types?
You’ve probably heard about embryonic stem cells (ESCs). These are derived from an embryo and they are controversial. None of the research on stem cell supplements reviewed here used ESCs. Then there are adult stem cells that live in your body and act as the repairmen. These come in many flavors, but the type I have focused on in this review are called mesenchymal stem cells (MSCs), the triathlete of adult stem cells. They can both direct tissue repair like a general contractor and also differentiate (turn into) many different cell types like bone, cartilage, muscles, tendon, etc… These cells also have subtypes that come from various tissues like bone marrow, fat, or elsewhere. While similar, these different MSC types are not the same.Best Stem Cell Supplements
1. Glucosamine and Chondroitin
Glucosamine can for example help mesenchymal stem cells to generate cartilage cells (R). Glucosamine can also improve stem cell proliferation in the gut (R,R).
Chondroitin also has real measurable effects on knee cartilage in actual patients. In one study, it reduced cartilage volume loss on MRI after 6 months (R). Glucosamine also seemed to help cartilage quality when measured on a specialized MRI (R). In another study, glucosamine reduced cartilage breakdown products (R). Finally, when compared to prescription Celebrex, the combination of glucosamine and chondroitin were better at improving function and reducing cartilage breakdown in the knee (R).
2. Curcumin (Turmeric)
The most commonly promoted anti-inflammatory supplements right now are curcumin and turmeric. Turmeric and curcumin are derived from the turmeric root with turmeric being the spice you know from Indian cooking, and curcumin one of the chemical compounds known as curcuminoids, which are believed to be biologically active. In addition, in order for curcumin to be absorbed in the gut, a black pepper extract is commonly required.In one study that used adipose MSCs to treat heart attacks, curcumin improved the viability of the cells, reduced scarring in the heart muscle being repaired, and promoted new blood vessel formation (R). In another involving bone marrow MSCs, curcumin improved bone formation (R).
The curcuminoids also impact arthritis through anti-inflammatory pathways and reducing inflammatory cytokines. All of these effects have translated into real measurable impacts on patients with knee arthritis (R). In other studies, Curcumin has been shown to be as effective as common NSAID anti-inflammatories such as Diclofenac (R).
To supplement curcumin with piperine, take 500 mg of the former with 5-6.7 mg of the latter, thrice a day (i.e., 1,500 mg of curcumin and 15-20 mg of piperine per day) (R).
3. Resveratrol and Pterostilbene
Resveratrol (RSVL) is a natural type of polyphenolic phytoestrogen and is mainly found in red grapes, blueberries, peanuts, and other plants. The effect of resveratrol on stem cell is well documented (R).- The lower end of supplementation tends to be for cardiovascular health, insulin sensitivity, and longevity for somebody who is otherwise unhealthy is 5-10mg daily. For persons who are otherwise healthy, dosages between the range of 150-445mg have been used (with no clear indication for what is the optimal dose).
- Supplementing for cerebral blood flow requires a dose in the 250-500mg range whereas supplementation for aromatase inhibition requires 500mg as well.
- Supplementation of resveratrol refers to trans-resveratrol exclusively.
4. Quercetin and Fisetin
This can be found in many fruits, vegetables, grains, and leaves. Kale and red onions are examples of foods that contains an appreciable amount of quercetin among many others. It comes with a bitter flavor and is commonly used as an ingredient in foods, beverages, and dietary supplements.Here are the benefits of quercetin:
- Antioxidant
- It supports mitochondria
- It can prevent the death of cells
- It can protect your body by reducing your stress levels
- It can serve as a natural antihistamine and can get rid of allergy symptoms
- It is a safe alternative to painkillers since it can treat arthritis and joint pain
- Research suggests that it can support stem cell growth and differentiation (R)
- Currently, there are no ideal amounts set by the scientific community. You can ask your doctor regarding this one to find out how much is needed based on your health's current status.
- Majority of supplements require 500mg and it has to be taken twice daily. But with quercetin, you can already experience the benefits even if you take something lesser than that considering that it's known to be diet rich.
- Dosages of quercetin used are in the range of 12.5 to 25mg per kg body weight, which translates to a range of 1,136-2,272mg daily consumption of quercetin when in isolation.
- It is suggested to supplement with other bioflavonoids such as resveratrol, genistein, or green tea catechins to increase the potency synergistically and theoretically get the benefits at a reduced level of intake.
- When looking for quercetin, the form of dihydrate has the apparent best bioavailability followed by glycosides, aglycone, and finally rutinoside.
5. NMN (nicotinamide mononucleotide)
NMN is a substance that increases NAD levels in our cells. NAD is a pivotal molecule to protect and repair DNA and the epigenome, including in stem cells.NMN can improve and protect stem cells such as mesenchymal stem cells that form bone and fat tissue (R,R).
6. Vitamin C and AKG (Alpha KetoGlutarate)
Vitamin C can also improve stem cell health (R,R).But ideally, vitamin C has help from alpha-ketoglutarate, given these two substances are substrates for important epigenetic enzymes, such as the TET enzymes (R).
7. Green Tea Extract
Green Tea Extract is incredibly potent thanks to its high number of polyphenols, which have been shown to:8. Glycine (Amino Acid)
Glycine is a naturally-occuring substance in our body; in fact, it’s an amino acid. However, during aging, levels of glycine decline.Glycine has shown to improve stem cell health (R,R). It can do this by protecting proteins in cells, or by inducing autophagy, which is the digestion of cellular waste.
9. Molecular Hydrogen
Molecular hydrogen is the smallest anti-oxidant. The ability of molecular hydrogen (H2) to protect the DNA and the mitochondria from oxidative damage may have beneficial effects on chronic diseases and cancer. But perhaps it could help slow down or reverse the aging process itself. A couple of cellular studies give us some interesting clues [R, R].It was already discovered that hydrogen can prolong the life of stem cells by reducing oxidative stress
(Biochem Biophys Res Commun. 2010).
A hydrogen-rich environment reduced both oxidative stress and aging in cells. Some scientists think
that drinking hydrogen water could increase longevity in humans (Circ J. 2016).
10. Olive oil and Mediterranean Diet
PubMed has indexed 30 research studies on olive oil and stem cell.
A Mediterranean diet rich in virgin olive oil is effective in boosting stem cells. A 4-week control study published in The American Journal of Clinical Nutrition (2011) showed that compared to those on a diet high in saturated fat or a diet low in fat but high in carbohydrates, those on a Mediterranean diet rich in virgin olive oil showed a significant doubling in their endothelial progenitor cell count in the blood.
What To Consider When Choosing The Best Stem Cell Supplements
When buying a new stem cell supplements, you want to make sure you choose the right one. While many factors can affect your decision, some general guidelines can help you choose the perfect stem cell supplements for your needs.Before becoming interested in stem cell supplements, you may have learned about the stem cell supplements industry. You may also have learned many things to understand, such as the quality of the stem cell supplements, what exactly it is made of, how much it costs, and how it compares with similar products. These factors will all make a difference in what kind of purchase you will make. This article gives tips on how to choose the best stem cell supplements.
Choosing the right stem cell supplements is always difficult because many factors exist. A few general questions should help you narrow down what kind of stem cell supplements you want to buy and how much you should pay.
- Is the stem cell supplements made of high-quality material?
- Is it durable and long-lasting?
- How much does it cost?
- Is the price reasonable?
- What kind of warranty does the seller offer?
- Are there any additional features with this stem cell supplements that might make your purchase worthwhile?
When choosing the best stem cell supplements, it is important to consider various factors. The following are some of the most important things you must consider when choosing a product.
Price
It is important to choose an affordable stem cell supplements. You should compare prices before buying to find one that matches your budget. If possible, do not be tempted by low prices because they might not be reliable. You will probably spend more money on repairs and replacements in the future than if you had bought a more reliable product in the first place.
The best way to get a good deal on a stem cell supplements is by shopping around. You can use the internet to find several retailers who sell similar products and then compare prices. This will help you to find a retailer that offers excellent value for money.
Feature
Another important factor is the stem cell supplements features and whether it meets your needs. The more features a model has, the higher the price. If you’re on a budget, look for a simple model with only the basic features. If you have more money to spend and want a model with lots of features, look for one that has more to offer. If you’re looking for a simple model, check out the stem cell supplements reviews. Some models are often praised for having fewer features but being easy to use and providing good performance.
Durability
If you’re using your stem cell supplements frequently or in harsh conditions, then durability becomes even more important than price because failing equipment can cause further damage or injuries if not working properly. Durability depends on several factors, including build quality, materials used in construction, and design features. Choosing a durable model will mean less downtime.
Ideally, you should use a durable product that can withstand heavy use. If possible, go for a product that is made from high-quality materials. This way, even if you use your stem cell supplements frequently, it will remain in good condition for a long time.
Budget
Another important factor that should influence your choice of stem cell supplements is your budget. If you have a tight budget, you should consider buying an affordable model instead of an expensive one that offers little benefit over cheaper models.
Brand Reputation
The major thing to look at is the brand reputation. You want to find a company that has been in business for a long time and has an excellent track record. If they have been around for years, they are doing something right and have built a good reputation among customers. Check out their website or research online to see what others have said about them.
Customer Support
If you want to know what your future stem cell supplements will be like, look at how the company handles its customers’ problems. If there are many complaints on forums and social networks about poor customer service, there are problems with this particular brand or model. It would be better to choose another brand if you care about your comfort and convenience.
Customer Reviews
Another important thing that should not be ignored is customer reviews. People who have already used stem cell supplements can share their impressions with other users, so it is worth reading them before making a purchase decision. In addition, if you have any questions regarding the product’s features or specifications, this information can also be found in the reviews.
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